Leo Caves, University of York: Computer simulation of the interactions and dynamics of biomolecules. Structure-dynamics-function relationships in proteins. Large-scale functional conformational changes. Intrinsic mechanical properties of biomolecules. Techniques of molecular dynamics, normal mode analysis, reaction path methods. Multivariate statistical analysis of biomolecular conformation: structural bioinformatics, homology modelling. Non-linear time-series analysis techniques applied to sequential biomolecular data streams (biophysical time-series, sequence data): wavelets, state-space reconstruction. Protein QSAR. Network modelling: Master equation treatments based on transition matrices. Hans Lehrach, Department Vertebrate Genomics in the Max Planck Institute for Molecular Genetics, Berlin. Name of the group: YAM (Yeast Analysis and Modelling). Short description: We will apply a strategy to characterise cellular processes consisting of the following parts: (1) Design of experiments to perturb specific subsystems according to modelling requirements, (2) High-throughput generation of experimental data by chip-technology,proteomics and metabolomics, (3) mathematical modelling, prediction of cellular responses, hypothesis testing and iterative model refinement, (4) integration of data and models in a global simulation tool. Yeast cells will be used as model organism, later application of tools and echnologies to vertebrates is envisaged. Barbara Pierscionek, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK. We are looking at the changes which occur in the optical elements of the eye with ageing. Techniques include computer simulations of the ocular system; ray tracing, fibre optic measurement, finite element analysis. Mathematical modelling of the lens and changes with occur with cataract formation, predictive analysis of the image degradation experienced by a cataract sufferer. Mathematical modelling of the corneal shape and optics. Charles Auffray, CNRS, Villejuif, France (charles.auffray@vjf.cnrs.fr). Name of the group: Genexpress/Systemoscope. Short description: in the frame of Expression Profile International Consortium (EPIC) initiative, we are organizing a collaboratory on Functional Genomics and Systems Biology for Human Health, with the plan develop pilot systems biology projects in the areas of immune system activation and infectious diseases (with HLA as an integrator), cancer and regeneration (with the cell cycle as an integrator), and neuromuscular system development and disease (with chromosome 21 as an integrator). The principal partners are : Magali Roux-Rouquié, Institut Pasteur, Paris, France; Ingemar Ernberg, Karolinska Institute, Stockholm, Sweden; Zhu Chen; Institute of Hematology, Shanghai, China; Leroy Hood, Institute for Systems Biology,Seattle, USA.   Wilhelm Ansorge, EMBL, Heidelberg, Area of excellence : --- DNA and Protein chips technology (existing chip yeast, mouse 15k soon 23k, human 55 000 ESTs---proteomics (mass spec), high resolution Protein differential expression systems (device developed by the group) novel fast method for monoclonal antibodies screening and production ---bioinformatic tools for expression analysis, data bases and data managements Role : --- DNA and Protein chip expression and interactions, function analysis --- Differential Protein expression---bioinformatics, (expression analysis and data bases, standardisation   Dr. Martin Bertau > >Institut fuer Biochemie > >Technische Universitaet Dresden > >01062 Dresden

ear Drs. Doutheil and Westerhoff,   I would like to express my interest in joining your initiatives on ESBIGH and the Silicon Yeast project. It might be already too late for the upcoming EoI submissions but due to a longer stay in the US I wasn't able to contact you before. My research interests cover genome-wide protein-protein interactions screens and the biofinormatics of these interactions. For more information see my web site:   http://itgmv1.fzk.de/www/itg/uetz/   Please respond to my main address: peter@uetz.de   Thanks a lot for your consideration.   Regards,   Peter Uetz