Silicon cell related papers by Westerhoff and friends. Please note: Not all links to pdf’s may be active.

270 Bakker, B.M., Michels, P.A.M., Opperdoes, F.R. and Westerhoff, H.V. (1999) What controls glycolysis in bloodstream form Trypanosoma brucei. J. Biol. Chem 274, 14551-14559. Code: http://www.bio.vu.nl/hwconf/papers/bb81.pdf

271 Bakker, B.M., Walsh, M.C., Ter Kuile, B.H., Mensonides, F.I.C., Michels, P.A.M., Opperdoes, F.R. and Westerhoff, H.V. (1999) Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. Proc. Nat. Acad. Sci. USA 96, 10098-10103. Code: http://www.bio.vu.nl/hwconf/papers/bb99.pdf

283 Bakker, B.M., Mensonides, F.I.C., Teusink, B., van Hoek, P., Michels, P.A.M. and Westerhoff, H.V. (2000) Compartmentation protects trypanosomes from the dangerous design of glycolysis. Proc. Natl. Acad. Sci USA 97, 2087-2092. Code: http://www.bio.vu.nl/hwconf/papers/ca38.pdf

289 Bruggeman, F.J., van Heeswijk, W.C., Boogerd, F.C. and Westerhoff, H.V. (2000) Macromolecular intelligence in mircoorganisms. Biol. Chem. 381, 965-972. Code: http://www.bio.vu.nl/hwconf/papers/ca76.pdf

292 Hoefnagel, M.H.N., Hugenholtz, J., Westerhoff, H.V. and Snoep, J.L. (2000) Modelling pyruvate distribution in Lactococcus lactis: a kinetic model to support metabolic engineering strategies. in Animating the cellular map (Hofmeyr, J.-H.S., Rohwer, J.M. and Snoep, J.L., eds.), pp. 243-247, Stellenbosch University Press, Stellenbosch, South Africa. Code: http://www.bio.vu.nl/hwconf/papers/ca72.pdf

293 Jeneson, J.A.L., Westerhoff, H.V. and Kushmerick, M.J. (2000) A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. American Journal of Physiology: Cell 279, C183-832. Code: http://www.bio.vu.nl/hwconf/papers/ca30.pdf

298 Michels, P.A.M., Bakker, B.M. and Westerhoff, H.V. (2000) On the mathematical modelling of metabolic pathways and its use in the identification of the most suitable drug target. in Tropical disease guidelines and issues: Discoveries and drug development. (Vial, H., Ridley, R. and Fairlamb, A., eds.), Vol. in press, World Health Organization. Code: http://www.bio.vu.nl/hwconf/papers/ca57.pdf

301 Rohwer, J.M., Meadow, N.D., Roseman, S., Westerhoff, H.V. and Postma, P.W. (2000) Understanding glucose transport by the bacterial phosphoenolpyruvate: Glycose phosphotransferase system on the basis of kinetic measurements in vitro. J. Biol. Chem. 275, 34909-34921. Code: http://www.bio.vu.nl/hwconf/papers/ca58.pdf

302 Saunders, N., Hornberg, J., Reijnders, W., Westerhoff, H. and van Spanning, R. (2000) The NosX and NirX proteins of Paracoccus denitrificans are functional homologues: their role in the maturation on nitrous oxide reductase. J Bacteriol 182, 5211-5217. Code: http://www.bio.vu.nl/hwconf/papers/ca62.pdf

304 Snoep, J.L., van der Weijden, C.C., Andersen, H.W., Westerhoff, H.V. and Jensen, P.R. (2000) Quantifying the importance of regulatory loops in homeostatic control mechanisms. Hierarchical control of DNA supercoiling. in Technological and Medical Implications of Metabolic Control Analysis. (Cornish-Bowden, A.a.C., M.L., ed.), Vol. in press, Kluwer Academic Publishers, Dordrecht, The Netherlands. Code: http://www.bio.vu.nl/hwconf/papers/ca45.pdf

308 Teusink, B., Passarge, J., Reijenga, C.A., Esgalhado, E., van der Weijden, C.C., Schepper, M., Walsh, M.C., van Dam, K., Westerhoff, H.V. and Snoep, J.L. (2000) Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes: Testing Biochemistry. Eur. J. Biochem. 267, 5313-5329. Code: http://www.bio.vu.nl/hwconf/papers/ca20.pdf

315 Westerhoff, H.V., Riethorst, A. and Jongsma, A.P.M. (2000) Relating multidrug resistance phenotypes to the kinetic properties of their drug efflux pumps. Eur J. Biochem. 267, 5355-5368. Code: http://www.bio.vu.nl/hwconf/papers/ba70.pdf

317 Wielinga, P.R., Westerhoff, H.V. and Lankelma, J. (2000) The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells. Eur. J. Biochem. 267, 649-657. Code: http://www.bio.vu.nl/hwconf/papers/ca35.pdf

320 Demin, O.V., Gorianin, I.I., Kholodenko, B.N. and Westerhoff, H.V. (2001) Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria (Russian). Mol. Biol. (Moscow) 35, 1095-1104. Code: http://www.bio.vu.nl/hwconf/papers/CB04.pdf

321 Francke, C., Postma, P.W., Westerhoff, H.V., Blom, J.G. and Peletier, M.A. (2001) Why the phosphotransferase system of Escherichia coli escapes the diffusion limitation of signal transduction, transport and metabolism that confronts mammalian cells. , Centrum voor Wiskunde en Informatica, Amsterdam - The Netherlands. Code: http://www.bio.vu.nl/hwconf/papers/cb18.pdf

336 Francke, C., Westerhoff, H.V., Blom, J.G. and Peletier, M.A. (2002) Flux control of the bacterial phosphoenolpyruvate: glucose phosphotransferase system and the effect of diffusion. Molecular Biology Reports 29, 21-26. Code: http://www.bio.vu.nl/hwconf/papers/cb10.pdf

337 Hoefnagel, M.H.N., Starrenburg, M.J.C., Martens, D.E., Hugenholtz, J., Kleerebezem, M., van Swam, I.I., Bongers, R., Westerhoff, H.V. and Snoep, J.L. (2002) Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. Microbiology 148, 1003-1013. Code: http://www.bio.vu.nl/hwconf/papers/ca94.pdf

347 Reijenga, K.A., Westerhoff, H.V., Kholodenko, B.N. and Snoep, J.L. (2002) Control analysis for autonomously oscillating biochemical networks. Biophys. J. 82, 99-108. Code: http://www.bio.vu.nl/hwconf/papers/ca89.pdf

349 Snoep, J.L., van der Weijden, C.C., Andersen, H.W., Westerhoff, H.V. and P.R., J. (2002) DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metaboic regulation of both topoisomerase I and DNA gyrase. Eur. J. Biochem 269, 1662-1669. Code: http://www.bio.vu.nl/hwconf/papers/ca88.pdf