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Jeantine Lunshof » Personal information

Jeantine E. Lunshof , Ph.D.

Philosopher, Bioethicist

Research

The focus of my current work as a philosopher and bioethicist is on research in the field of human genetics and genomics, and systems biology. Since September 2008 I am an Assistant Professor at the Faculty of Health, Medicine and Life Sciences at Maastricht University (Netherlands). I am an Affiliated Researcher at the Department of Molecular Cell Physiology of the Faculty of Earth and Life Sciences, VU University Amsterdam. My current work is on the theoretical and normative aspects of Pharmacogenomics, Personalized Medicine, and Molecular Technologies including Biological Engineering. The Philosophy of Systems Biology is a major pillar of the theoretical framework underlying my research. Further interests include exploring the usefulness of philosophical discourse practices for dealing with genomics' benchside questions. Since 2006 I have been an ethics consultant to the Personal Genome Project at the Genetics Department of Harvard Medical School (http://www.personalgenomes.org).) and since 2010 also to the Center for Excellence in Genomic Science (CEGS), Center for Causal Consequences of Variation (CCV) (http://ccv.med.harvard.edu) , both directed by George Church. Since 2006, I am an Affiliate Member of the NIH/NIGMS Pharmacogenomics Research Network (PGRN). I hold an affiliation with CESAGEN (University of Lancaster & Cardiff University, UK), and I am an Individual Member of the P3G Consortium

Since 1992, I have been involved in international research collaborations on ethical issues in human genetics.

Education

After receiving my Bachelor in Philosophy, with Tibetan Language & Cultural Studies (Hamburg University, Germany) as a minor, I graduated from the University of Amsterdam (UvA) with an MA in Philosophy (Systemic Philosophy, Ethics, Medical Ethics) and Health Law. I received my PhD from VU University Amsterdam. Holding a RN as well, I was involved in clinical research at the clinic of the Netherlands Cancer Institute in Amsterdam from 1981 until 1989. From 1993 to 1996 I carried out research on normative issues in the context of human genetics at the Institute for Human Genetics of Heidelberg University, Germany. In Germany and in the Netherlands I gave lectures and seminars on ethical issues in clinical genetics and genetic counseling, as well as on end-of-life decision-making and relevant Dutch legislation, and both topics were subjects of earlier publications (see publication list).

Please refer to the Projects page for detailed biographical and professional information.

Memberships

• Affiliated Researcher at CESAGEN, ESRC Centre for Economic and Social Aspects of Genomics,
University of Lancaster & Cardiff University, UK
• Affiliate Member NIH-NIGMS Pharmacogenomics Research Network (PGRN), USA
http://pgrn.org/display/pgrnwebsite/PIE+Profile
• International Association of Bioethics
• Human Genome Organisation (HUGO)
• Individual Member Public Population Project in Genomics (P3G), Canada
• Individual Member European Society of Human Genetics
• Nederlandse Vereniging voor Bioethiek (Netherlands Association of Bioethics)
• Vereniging voor Filosofische Praktijk
• Akademie für Ethik in der Medizin (Academy of Medical Ethics, Germany)

Editorial Board

• Genome Medicine
http://genomemedicine.com/about/edboard
• Personalized Medicine
http://www.futuremedicine.com/page/journal/pme/editors.jsp
• Current Pharmacogenomics and Personalized Medicine
http://www.bentham.org/cppm/index.htm
• Human Genomics and Proteomics
http://www.sage-hindawi.com/journals/hgp/
• Frontiers in Pharmacogenetics and Pharmacogenomics http://www.frontiersin.org/pharmacogenetics_and_pharmacogenomics

Selected Publications

David Gurwitz, Jeantine E. Lunshof. Personalized participatory medicine: sharing knowledge and uncertainty. Genome Medicine (2011) 3:69-70

Kolodkin A, Boogerd FC, Plant N, Bruggeman FJ, Goncharuk V, Lunshof J, Moreno-Sanchez R, Yilmaz N, Bakker BM, Snoep JL, Balling R, Westerhoff HV. Emergence of the silicon human and network targeting drugs. European Journal of Pharmaceutical Sciences (2011) (in press) doi:10.1016/j.ejps.2011.06.006.

David Gurwitz, Jeantine E. Lunshof. A deserving role for the National Center for Advancing Translational Sciences. Lancet (2011) 377:1745-1746 [Letter].

Becla L, Lunshof JE, Gurwitz D, Schulte In den Bäumen T, Westerhoff HV, Lange BM, Brand A. Health technology assessment in the era of personalized health care. International Journal of Technology Assessment in Health Care (2011) 27(2):118-26.

Jeantine E. Lunshof, Ruth Chadwick. Editorial. Genetic and Genomic Research – Changing Patterns of Accountability. Accountability in Research (2011) 18(3):121-131. Guest Editor Special Issue: Impact of Genomics Research on Ethical Issues.

Jeantine E Lunshof, Jason Bobe, John Aach, Misha Angrist, Joseph V Thakuria, Daniel B Vorhaus, Margret R Hoehe, George M Church. Personal genomes in progress: from the Human Genome Project to the Personal Genome Project. Dialogues in Clinical Neuroscience

Elaine R Mardis, Jeantine E Lunshof. A focus on personal genomics. Personalized Medicine, (2009) 6(6):603-606. Guest Editor of Special Issue: Personal Genomics.
David Gurwitz, Isabel Fortier, Jeantine E.Lunshof and Bartha Maria Knoppers.Children and Population Biobanks. Science, (2009) vol 325, 818:819.

David Gurwitz and Jeantine E.Lunshof. Ancestry in translational genomic
medicine: handle with care. Genome Medicine, (2009) 1:24.
http://genomemedicine.com/content/1/2/24

D Gurwitz, JE Lunshof. Personalized Pharmacotherapy: Genotypes, Biomarkers, and Beyond. (Letter). Clinical Pharmacology & Therapeutics, Advance online publication 12 November 2008. doi:10.1038/clpt2008228.

Barbara Prainsack, Jenny Reardon, Richard Hindmarsh, Herbert Gottweis, Ursula Naue & Jeantine E. Lunshof. Misdirected precaution. Nature, (2008) 456:34-35.

Jeantine E. Lunshof. The new genomics and personal genome information: ethical issues. In: M. Janitz (Ed.) Next generation Genome Sequencing. Wiley-VCH, Weinheim. 2008. p.245-254.

Jeantine E Lunshof, Ruth Chadwick, Daniel B. Vorhaus and George M. Church. From genetic privacy to open consent. Nature Reviews Genetics, (2008) 9:406-411.

Jeantine E. Lunshof, Ruth Chadwick, George M. Church.
Hippocrates revisited? Old ideals and new realities. Genomic Medicine, (2008) 2:1-3.
http://www.springerlink.com/content/x15504287j448mpn/fulltext.pdf

Russ B. Altman, Neal Benowitz, David Gurwitz, Jeantine Lunshof, Mary Relling, Jatinder Lamba, Eric Wieben, Sean Mooney, Kathleen Giacomini, Scott Weiss, Julie A. Johnson, Howard McLeod, David Flockhart, Richard Weinshilboum, Alan R. Shuldiner, Dan Roden, Ronald M. Krauss, Mark Ratain
Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing.
Pharmacogenomics, (2007) 8 (5) 519.

Jeantine Lunshof . A just distribution of benefits. Reply to Question of the Year. Nature Genetics, 2 April 2007. http://www.nature.com/ng/qoty/index.html

Lunshof JE. Personalized medicine: new perspectives – new ethics? Personalized Medicine, (2006) 3 (2) 187-1944.

Lunshof JE. Teaching and practicing pharmacogenomics: a complex matter. Pharmacogenomics, (2006) 7 (2) 243-246.

Lunshof JE, Pirmohamed M, Gurwitz D. Personalized medicine: decades away? Pharmacogenomics, (2006) 7 (2) 237-241.

Lunshof JE . Desperate times call for desperate measures. Nature Reviews Genetics, (2006) 7, 162.

Gurwitz D, Lunshof JE, Altman RB. A Call for the Creation of Personalized Medicine Databases.
Nature Reviews Drug Discovery, (2006) 5, 23-26.