A model to analyze effects of complex mixtures on survival
Baas, J., Jager, T. and Kooijman, S. A. L. M.
A model to analyze effects of complex mixtures on survival.
Ecotox. Environ. Saf. 72: 669 - 676
In ecotoxicology there is a growing interest in effects of
mixtures. The aim of this research was to develop a biology based
model that describes effects of mixtures on survival in time. The
model works from the individual compounds in the mixture. Such an
approach requires parameters for each individual compound in the
mixture. For narcotic compounds we underpinned theoretical relations
between the toxic parameters and the log Kow with experimental data by
analyzing almost 300 datasets from the open literature, allowing a
vast reduction in effort in the assessment of effects of mixtures. To
illustrate the use of the model we simulated the effect of a mixture
of 14 PAHs on the survival of Pimephalus promelas. The simulation
showed that due to the combined effect of the compounds in the mixture
effects can be seen at very low concentrations.
This paper was highlighted by Ecotox. Environ. Saf.