Parametric analyses of mortality rates in bioassays
Kooijman, S. A. L. M. 1981.
Parametric analyses of mortality rates in bioassays
Water Research 15: 107 - 119
Abstract
Parametric analyses are presented for the mortality rates obtained
from bioassays. In this paper we base the large sample theory on the
estimation and testing of no. small and ultimate effects of test
compounds on the maximum likelihood principle. The relevance of the LC
50 in toxicity tests and hazard evaluation is discussed. The analysis
of the accumulation and elimination behaviour of test compounds
through mortality rates is described. A method is presented for
estimating the disappearance rate of the test compound in a semistatic
bioassay from the mortality rates of the test organisms. The
application of the theory is illustrated by several examples.