Ecotoxicological applications of Dynamic Energy Budget theory
Kooijman, S. A. L. M., Baas, J., Bontje, D., Broerse, M., Gestel, C. van and Jager, T. 2009.
Ecotoxicological applications of Dynamic Energy Budget theory.
In: Devillers, J. (ed)Ecotoxicological Modeling, Springer, p 237-259
Abstract
The Dynamic Energy Budget (DEB) theory for metabolic organisation
specifies quantitatively the processes of uptake of substrate by
organisms and its use for the purpose of maintenance, growth,
maturation and reproduction. It applies to all organisms. Animals
are special because they typically feed on other organisms. This
couples the uptake of the different required substrates, and their
energetics can, therefore, be captured realistically with a single
reserve and a single structure compartment in biomass. Effects of
chemical compounds (e.g.\ toxicants) are included by linking
parameter values to internal concentrations. This involves a
toxico-kinetic module that is linked to the DEB, in terms of
uptake, elimination and (metabolic) transformation of the
compounds. The core of the kinetic module is the simple
one-compartment model, but extensions and modifications are
required to link it to DEBs. We discuss how these extensions
relate to each other and how they can be organised in a coherent
framework that deals with effects of compounds with varying
concentrations and with mixtures of chemicals. For the
one-compartment model and its extensions, as well as for the
standard DEB model for individual organisms, theory is available
for the co-variation of parameter values among different
applications, which facilitates model applications and
extrapolations.