The Analysis of Aquatic Toxicity Data

By S.A.L.M. Kooijman & J.J.M. Bedaux

VU University Press, Amsterdam
ISBN 90-5383-477-X

The book can be ordered directly via the publisher: info@vuboekhandel.nl
or through your own book store when you give them the ISBN number. Costs about 25 euro.

Errata

Standardized bioassays are frequently used to access the toxicity of chemical compounds. The standard NOEC/EC50-analysis of these bioassays suffers from several problems.

This book describes a novel analysis that solves these problems. The application of this new analysis is easy with the software package DEBtox, which accompanies this book.

After a general introduction by the Dutch Ministry of the Environment, the scientific background of the analysis is discussed, followed by explanations of the mathematical models and statistical aspects. The final chapter describes the use of DEBtox in non-technical terms.

DEBtox runs under MS-Windows on a PC (486 or higher) and on SunOS 4.1.3/Solaris 2.5.

This book will be of interest to all those involved in the assessment of the toxicity of chemical compounds. The biological backgrounds are discussed in the DEB-book.

Summary of Contents

1) Process oriented descriptions of toxic effects
Conceptual aspects of effect studies, involving exposure, toxico-kinetics, change of target parameters, effects on endpoints: survival, growth, reproduction
2) Statistical properties of no-effect concentrations
Small sample behaviour of the partial likelihood function for No-Effect concentrations
3) Statistical analysis of bioassays, based on hazard modelling
Maximum likelihood estimation of the parameters (blank mortality rate, elimination rate, No-Effect concentration and killing rate, from multinomially distributed samples
4) Analysis of toxicity tests on fish growth
Non-linear regression analysis for effects on growth for chemicals with different modes of action
5) Analysis of toxicity tests on Daphnia survival and reproduction
Non-linear regression analysis for effects on reproduction for chemicals with different modes of action
6) No-effect concentrations in algal growth inhibition tests
Non-linear regression analysis for effects on population-growth for chemicals with different modes of action
7) DEBtox
Manual for software package DEBtox, and a discussion of the results

Full text in pdf format

Errata in html to The Analysis of Aquatic Toxicity Data, or in LaTeX format.

DEBtool support is available for this book.


Go to the DEBtox pages