lecturer: Bas Kooijman
title: Approache to modelling metabolism: past and current
date: 2019/04/04
location: Institut Universitaire Européen de la Mer Technopôle Brest-Iroise, 
   Rue Dumont D'urville, 29280 Plouzané

Summary:
Before we can consider modelling of metabolism, we first need to review what metabolism is and how it evolved, which is what I will do. 
The modelling of metabolsim can be classified in 2 categories: 
the biochemical one, which follows specified compounds, and the pool approach, which follows one or more metabolic pools of constant chemical composition. 
Each has its own strong and weak points. 
The simplest and most popular pool-approach delineates just one pool, called biomass, and has a long history that I will briefly review. 
This includes my views on confusion about the models of Putter and von Bertalannfy, the role of allometric functions, and the limitations of respiration as a quantification 
  of metabolic rate. 
Then I will discuss the possible delineations of two pools in the light of weak homestasis, maintaining a constant chemical composition during growth in (chemically) 
  constant environments.