Event: DEB2025 School: 26 May-3 June Location: Univ. of Crete, Iraklion, Greece Date: 5 Jun 2023, 16:30-17:30 Lecturer: Bas Kooijman (emeritus); bas.kooijman@vu.nl Affiliation: A-Life, VU University Amsterdam Title: Life, from molecules to system earth This lecture discusses conceptual aspects of links between the molecular and system earth levels of life and the role of individuals. Limitations of mathematical modelling are discussed in the light of scales in space and time. Ideas are presented on the evolution of the central metabolism and how they can be used to delineate metabolic mudules between molecules and individuals. Mass and energy balances at the population level can structure canonical communities is ways that repect the syntrophic nature of life on earth. Geochemical recycling processes shaped the evolution of life; examples are given. References: Meer, J. van der, Hin, V. Oort, P. van & Wolfshaar, K.E. van der 2022 A simple DEB-based ecosystem model. Cons. Physiol. 10: coac057 Kooijman, S.A.L.M., Lika, K., Augustine, S., Marn, N. & Kooi, B.W. 2020 The energetic basis of population growth in animal kingdom. Ecol. Mod, 428: 109055 Kooijman, S.A.L.M. & Troost, T.A. 2007 Quantitative steps in the evolution of metabolic organisation as specified by the Dynamic Energy Budget theory. Biol. Rev 82: 1-30 Meer, J. van der 2016 A paradox in individual-based models of populations. Cons. Physiol. 4 cow023 Kooijman, S.A.L.M. & Hengeveld, 2005 The symbiontic nature of metabolic evolution. In: Reydon & Hemerik (eds): current themes in Theoretical Biology Springer Kooijman, S.A.L.M. 2004 On the coevolution of life and its environment. In: Schneider et al (eds): Scientists Debate Gaia; the next century. Cambridge, Mass Kooijman, S.A.L.M, Auger, P., Poggiale, J.C. & Kooi, B.W. 2003 Quantitative steps in symbiogenesis and the evolution of homeostasis. Biol. Rev. 78: 435-463 Nisbet, R.M., Muller, E.B., Lika, K. & Kooijman, S.A.L.M. 2000 From molecules to ecosystems through Dynamic Energy Budget models. J. Anim. Ecol. 69: 913-926