A generic toxicokinetic model for persistent lipophilic compounds in humans: an application to TCDD
Molen, G. W. van der, Kooijman, S. A. L. M. and Slob, W.
A generic toxicokinetic model for persistent lipophilic compounds in humans: an application to TCDD.
Fundam. Appl. Toxicol. 31: 83 - 94.
This paper discusses a toxicokinetic model describing the distribution
of TCDD in the human body during a lifetime. The model divides the
body into several physiological compartments, their weights being
functions of age. Ingested TCDD is instantaneously distributed over
all compartments according to their lipid content. The liver
eliminates TCDD from the body by a first-order process. Intake depends
on age, as estimated from food consumption survey data combined with
data on TCDD concentrations in various foods. It is shown that
historical changes in intake, due to changes in environmental
concentrations and in dietary habits, should be taken into account as
well. Elimination rate and bioavailability, the only unknown
parameters in the model, were estimated by calibrating the model to
human data on internal concentrations. The generic formulation of the
model makes it suitable for slowly eliminated lipophilic compounds in