# The Analysis of Aquatic Toxicity Data

By S.A.L.M. Kooijman & J.J.M. Bedaux

VU University Press, Amsterdam

ISBN 90-5383-477-X

The book can be ordered directly via the publisher:
info@vuboekhandel.nl

or through your own book store when you give them the ISBN number.
Costs about 25 euro.
Errata

Standardized bioassays are frequently used to access the toxicity of
chemical compounds. The standard NOEC/EC50-analysis of these bioassays
suffers from several problems.

This book describes a novel analysis that solves these
problems. The application of this new analysis is easy with the
software package DEBtox, which
accompanies this book.

After a general introduction by the Dutch Ministry of the
Environment, the scientific background of the analysis is discussed,
followed by explanations of the mathematical models and statistical
aspects. The final chapter describes the use of DEBtox in
non-technical terms.

DEBtox runs under MS-Windows on a PC (486 or higher) and on SunOS
4.1.3/Solaris 2.5.

This book will be of interest to all those involved in the
assessment of the toxicity of chemical compounds. The biological
backgrounds are discussed in the
DEB-book.

## Summary of Contents

**1) Process oriented descriptions of toxic effects**
- Conceptual aspects of effect studies, involving exposure,
toxico-kinetics, change of target parameters, effects on endpoints:
survival, growth, reproduction
**2) Statistical properties of no-effect concentrations**
- Small sample behaviour of the partial likelihood function for No-Effect
concentrations
**3) Statistical analysis of bioassays, based on hazard modelling**
- Maximum likelihood estimation of the parameters (blank mortality rate,
elimination rate, No-Effect concentration and killing rate, from
multinomially distributed samples
**4) Analysis of toxicity tests on fish growth**
- Non-linear regression analysis for effects on growth for chemicals
with different modes of action
**5) Analysis of toxicity tests on ***Daphnia* survival and reproduction
- Non-linear regression analysis for effects on reproduction for chemicals
with different modes of action
**6) No-effect concentrations in algal growth inhibition tests**
- Non-linear regression analysis for effects on population-growth for
chemicals with different modes of action
**7) DEBtox**
- Manual for software package DEBtox, and a discussion of the results

Errata in html
to The Analysis of Aquatic Toxicity Data, or in LaTeX format.

DEBtool
support is available for this book.

Go to the DEBtox pages